Genetic Testing
Elevated homocysteine (Hcy) levels have been link to psychiatric disorders such as schizophrenia depression, and bipolar disorder. A study involving 191first-episode inpatients aged 18-40 years found that those with psychiatric conditions had significantly higher Hcy levels compared to healthy controls. Notably, male patients exhibited higher Hcy levels across several disorders, including schizophrenia and major depressive disorder. However, no significant differences in Hcy levels were observed among the various psychiatric disorders studied, (Fan et al, 2024).
Homocysteine and Psychiatric Symptoms
These finding suggest that elevated Hcy may play a role in the development of psychiatric symptoms, particularly in men.
The Effects of Plasma Homocysteine Level on the Risk of Three Major Psychiatric Disorders: A Mendelian Randomization Study
Recent research highlights the connection between elevated homocysteine (Hcy) levels and schizophrenia, a chronic and disabling mental health disorder, has been associated with higher levels of Hcy compared to healthy individuals, suggesting its potential role in the disorder's pathophysiology. This study focused on FEDN patients, a group not influenced by medication, to better understand Hcy's impact, (Yang et al, 2022).
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Increased serum homocysteine in first episode and drug-naïve individuals with schizophrenia: sex differences and correlations with clinical symptoms
Studies have identified a link between elevated levels of homocystine (Hcy), and amino acid in the body, and an increased risk of certain mental health conditions, such as schizophrenia (SCZ) and bipolar disorder type I (BD-I). Hcy can contribute to brain cell damage and impair cognitive function, potentially playing a role in these disorders, (Yang et al, 2022).​​
B12 for Benefits of Lowering Hcy Levels
How Atomic Mindworks use Genetic Result for Personalized Care
At Atomic Mindworks we specialize in individual medication management by integrating genetic reviews, including assessment of MTHFR, MTRR, MTR, and COMT genes. Understanding a patient's genetic profile allows us to tailor treatments that address specific metabolic pathways, such as those involving homocysteine metabolism.
Optimizing Tretment with Genetic Insights
By considering these genetic factors, we aim to optimize therapeutic outcomes and reduce potential side effects, providing personalized care for each patient